The J. Marion Sims Letters, 1858-59 and 1880-1881, consist of four original letters from J. Marion Sims to Gen. Waddy Thompson of Greenville, South Carolina (1858-1859); to O.B. Mayer (1880); and Tom Taylor (1881). His letters refer to patients suffering with fibrous tumors of the uterus and ovarian cysts or tumors. He also inquires of a physician who treated a patient with rectal alimentation. The letters provide detailed accounts of his techniques in attempting to treat the patients.